Our research - work packages

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THE PROGRAM IS DIVIDED INTO FIVE WORK PACKAGES (WP), EACH WITH DIFFERENT SCIENTIFIC TASKS.

 

WP 1: EXPOSURE, FATE AND LIFE CYCLE ASSESSMENTS

...will provide new insights on flows and transformations of nanomaterials (NMs) through the technosphere, their release into the biosphere and the fate of the NMs in the environment.

  • Material flow models that predict the emissions of nanomaterials through the life cycle of products and applications in the technosphere.
  • Analytical tools to detect, characterize and track nanomaterials in the environment.
  • Mimicking of environmental conditions to address follow agglomeration, dissolution, complexation and sedimentation.
  • Advanced multiscale fate and transport modelsthat are balanced between molecular process descriptions and environmental relevancy. State of the art physical chemistry models to describe interfacial phenomena will be linked to complexity science simulations. Simulation of the buildup of fractal-like heteroagglomerates between natural colloidal matter and synthetic nanoparticles.
  • Life cycle assessment of SiO2 and graphene will be explored and conducted with special focus on how to handle data scarcity and uncertainties.

WP 2: THE MOLECULAR NANOBIOINTERFACE

...will give new understandning on how the formation of a primary corona of environmental organic material on NPs influences subsequent interactions between NPs and organisms and biomolecules.

  • Describe how differences in the first environmental corona change the formation of subsequent biomolecule coronas formed after uptake of NPs by organisms in a food web.
  • In detail describe the molecular interactions between the environmental corona and proteins and biological barriers.
  • Elucidate the influence of biomolecule coronas on metal-containing NPs on stability and surface reactivity in aqueous compartments of different chemistry.
  • Generalisation of the importance of NP structure on formation of organic coronas and biomolecule coronas and particles.
  • Provide new understanding of the molecular nanobiointerface which can be linked to the effects of the NPs, with different corona, on cells and aquatic organisms in WP3.

WP 3: INTEGRATED HAZARD ASSESSMENTS

...will provide specific details on the relation between physico-chemical properties and the environmental hazards of selected NPs, but will also broaden the scope of such QSAR-analyses with respect to biological complexity.

  • Test organisms representative for the major trophic levels in aquatic ecosystems
    • primary producer (algae)
    • consumer (invertebrates, fish)
    • destruents (bacteria)
  • Systems span important levels of biological complexity
    • sub-cellular systems
    • organismic systems
    • ecological systems
  • Provides systematic data for human health and environmental hazard assessment
  • Provides the data basis for developing a tiered, integrated hazard and risk assessment approach
    • common primary molecular interactions are explored with a view on human as well as environmental assessments
    • specific higher-level effects and modes of action are described in dedicated assays

WP 4: SOCIAL DIMENSIONS OF NANOSAFETY

...will provide new insights regarding perceptions of societal actors including industry, government, experts, and non-government organisations regarding potential risks and benefits of nanotechnology.

  • Update on the state of the art international research on risk regulation of NMs.
  • Update on risk regulation policy of NMs within the EU involving networks of actors including government agencies, NGOs, industry, scientific experts and the media.
  • Update on existing "screening-level" environmental risk assessment methods, including risk ranking and control-banding.
  • Original research on risk perception of NMs within Swedish society and among stakeholders.
  • Development of generic and science-based "screening–level" environmental risk assessments methods of NM
  • Application of developed methods on the project case studies
  • Original research on risk management of NMs within Swedish society by a broad array
  • of societal actors (government agencies, NGOs, industry, the media)

WP 5: NANOTECHNOLOGICAL SOLUTIONS TO ENVIRONMENTAL PROBLEMS

...will target the design of novel silica nanoproducts aimed for environmental applications. The synthesis of tracker-silica NPs is proposed to allow detection of silicia NPs under environmentally and biologically relevant conditions.

  • Synthesis of tracker-SiO2 NPs:
    • Interacting with on-going PhD project at Chalmers
    • where a tool box of modified silica is prepared

Have a question?

Call: +46 31-772 10 00

Email: info@mistraenvironmentalnanosafety.org

Contact information

Mistra Environmental Nanosafety

www.mistraenvironmentalnanosafety.org

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